白血病女孩被艾滋病毒奇迹治愈(英语)

时间:2021-12-31 作者:学乐网

下面是学习啦小编整理的白血病女孩被艾滋病毒奇迹治愈, 希望对大家有帮助。

The cancer girl cured by the HIV virus: Seven-year-old makes extraordinary recovery after U.S. doctors re-wire her immune system to destroy leukaemia cells

In April this year, Emily Whitehead's family had almost given up hope.

The brave six-year-old had been fighting leukaemia for two years, only to relapse for a second time during intensive chemotherapy treatment in February.

Doctors had exhausted all the traditional treatments as Emily could not remain in remission for long enough to attempt a bone marrow transplant. So her desperate parents, Kari and Tom, started looking at more radical options.

Fighting fit: Emily (seen left during treatment in April) has now been in remission from cancer for seven months

'We made the decision that we needed to go somewhere else,' said Mrs Whitehead.

'We needed to try something new, different and cutting-edge.'

So they turned to the Cancer Center at The Children’s Hospital of Philadelphia, which is involved in testing a pioneering new therapy.

Doctors suggested they sign Emily up to a clinical trial that would use a disabled form of HIV to carry cancer-fighting genes into her T-cells (disease fighting cells). The hope was that this would re-programme her immune system to recognise the cancer cells and start killing them.

Several adults had already been enrolled in the study at the Hospital of the University of Pennsylvania and had responded well, but as it was so new the treatment wasn't without risks. But time was running out for Emily, who is also known as Emma.

Mr Whitehead said: 'We were told that we were down to 48 hours of making a decision or she could start having organ failure.'

They comforted themselves with the knowledge that even if the treatment didn't work, it would provide doctors with information that could help them save other sick children.

So on April 17, the then six-year-old became the first child to have the therapy known as CTL019.

Emily during her therapy – at first she suffered an adverse reaction, which was treated with an arthritis drug

Now in remission, Emily enjoys walking her dog who comforted her when she was ill

The family had been warned Emily could experience flu-like symptoms a few days after her re-engineered T-cells were injected back into her.

But her symptoms were far more serious than doctors anticipated. She became critically ill and was admitted to intensive care at the children's hospital. On April 24, doctors told her parents she had a one in 1,000 chance of surviving the night.

Trial leader Dr Stephan Grupp and his team realised that the level of a certain protein had become very elevated as a result of the T-cells growing in Emily's body.

This same protein is involved in rheumatoid arthritis, and there is a drug for that disease that turns off production of that particular protein.

The team administered the drug to Emily, with dramatic results. Almost overnight, her breathing improved, her fever dropped and her blood pressure was back to normal.

Mrs Whitehead said Emily inspired them with how she coped.

'She's extremely smart and creative. She's funny – she makes us laugh all the time. She never complains,' she said.

Kira and Tom faced the agonising decision of whether or not to put their daughter forward for a clinical trial

Her husband added: 'She told us from the beginning that she would continue to fight and do what we asked as long as we were there with her. We've stuck together as a team. She's definitely our hero.'

Several weeks after her T-cell infusion, they were able to conduct a bone marrow test to find out if the therapy had worked.

'Three weeks after receiving the treatment, she was in remission,' said Dr Grupp.

'Emily completely responded to her T-cell therapy. We checked her bone marrow for the possibility of disease again at three months and six months out from her treatment, and she still has no disease whatsoever. The cancer-fighting T-cells are still there in her body.'

He added that they need to see the remission go on for a couple of years before they can think about whether she is cured or not.

But, after spending years in treatment, Emily went home in June and now enjoys going to school, playing football and walking her dog Lucy.

'T-cell therapy was really the only option left for Emily,' said Mr Whitehead.

'But we entered her into the trial really hopeful, and from the very beginning we just really had a good feeling about it. So all along we said, "it just has to work, it has to work for Emily" – and it did.'

The scientists said although the results were very promising, much more research needs to be done to see whether the therapy is a viable, safe and long-term solution for controlling certain cancers in children and adults

Ken Campbell, Clinical Information Officer at Leukaemia & Lymphoma Research, said the results of the study were encouraging for both children and adults diagnosed with leukaemia.

'Treatments which modify the body’s own immune system to fight leukaemia have shown much promise in recent years,' he said.

'What is significant about [the] therapy is that the severe side-effects associated with this form of treatment seem to be greatly reduced when combined with other drugs.

'This is a small study of just 12 patients. Larger clinical trials are needed to determine how effective this treatment could be and as a result it should be some time before it is available in the UK.'

Researchers from the University of Pennsylvania and Children’s Hospital of Philadelphia presented their latest findings at the American Society of Hematology’s annual meeting in Atlanta.

They found nine out of 12 patients in the trial, which included Emily and one other child, responded to the treatment. Their goal is to treat another 12 patients over the next year.

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